Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | vineri, 19 iulie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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PHYSIOLOGY OF BLOOD COAGULATION
B. Ţuţuianu
Clinica Anestezie Terapie Intensivă, Spitalul „Sf. Spiridon” Iaşi
Jurnalul de chirurgie 2007; 3 (2):102-109
Full text: PDF Format (Romana/Romanian)

Abstract:

Untill the XIXth century we knew very little about coagulation and haemostasis, most of our knowledge being based on observations. The discovery of thrombin, platelets, fibrinogen and calcium led to one of the most important theories (Paul Moravitz, 1890), which gave a scientific explanation of the haemostasis, describing the main steps of coagulation. Further on, the discovery of coagulation factors, of vitamin K, of heparin and of coagulation tests offered the ground for a new theory, namely the classical theory of the coagulation cascade (MacFarlane RG, 1964). At the end of the XXth century a new drug (Novoseven) proved to be efficient in obtaining haemostasis (not only in patients with hemophilia but also in other bleeding situations). This finding together with some unsolved questions (for example why patients with deficiency  of FXII do not have a tendency to bleed,) drove to a new theory which emphasizes the role of specific cells in coagulation. According to this theory, there are two types of cells involved: the tissue factor bearing cells (extravascular) and platelets (intravascular). These cells need to make contact through a discontinuation of the vessel wall in order to initiate the coagulation process. The reactions take place in three phases: initiation, amplification and propagation. This is the cell-based theory of coagulation.

KEYWORDS: COAGULATION, COAGULATION CASCADE, CELL-BASED MODEL

Corespondenţă: Dr. Bogdan Ţuţuianu, Clinica Anestezie Terapie Intensivă, Spitalul „Sf. Spiridon”, Bd. Independenţei, nr. 1, 700111, Iaşi; e-mail:
Correspondence to: Bărbulescu Marius MD; e-mail:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.