Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | vineri, 19 iulie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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CHEMOTHERAPY IN ADVANCED GASTRIC CANCER: PRESENT STANDARDS
L. Miron, M. Marinca
Disciplina de Oncologie, Facultatea de Medicină
Universitatea de Medicină şi Farmacie „Gr.T. Popa” Iaşi
Jurnalul de chirurgie 2007; 3 (2):110-116
Full text: PDF Format (Romana/Romanian)

Abstract:

Despite a sharp decline of its incidence during the second half of the 20th century, gastric cancer remains the second leading cause of cancer mortality in the world. Most gastric cancer patients are diagnosed when the tumor is inoperable. For these patients, systemic chemotherapy remains the main treatment option. Although a large number of chemotherapy regimens have been tested in randomized studies, there is no globally accepted standard of care, and uncertainty regarding the choice of the regimen persists. Irrespective of the positive impact of any presently available chemotherapy, the prognosis of patients with advanced gastric cancer remains desperate, with a median survival of only 7 to 10 months in most larger clinical studies. The best survival results are achieved with three-drug regimens containing 5-fluorouracil, an anthracycline and cisplatin. Future applications of newer cytotoxic drugs, targeted therapies and integration of molecular determinants of tumor behavior, prognosis and response to therapy may ultimately help to improve current standards and facilitate the delivery of more tailored and efficient therapeutic interventions.

KEYWORDS: ADVANCED GASTRIC CANCER, SURGERY, CHEMOTHERAPY, RESULTS

Corespondenţă: Dr. Lucian Miron, Clinica de Oncologie, Spitalul „Sf. Spiridon” Iaşi, Bd. Independenţei, nr. 1, 700111, Iaşi; e-mail:



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.