Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | sâmbătă, 16 februarie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
English
British Flag| Romana Romanian Flag
 
Creditare EMC
Colegiul Medicilor
Va invitam sa va inregistrati/abonati la Jurnalul de chirurgie pentru a beneficia de creditare EMC
User

Parola

Tine minte
Ti-ai uitat parola?
Syndicate

Advertisement

Elmed

Estima

Liamed

Listare E-mail

BIOLOGICAL EVENTS IN THE METASTATIC CASCADE ASSOCIATED TO COLORECTAL CANCER
Irina-Draga Căruntu (1), Simona Eliza Giuşcă (2), Gioconda Dobrescu (1)
(1) Department of Histology
(2) First Surgical Clinic „I. Tănăsescu-Vl. Buţureanu”
University of Medicine and Pharmacy "Gr. T. Popa" Iaşi
Jurnalul de chirurgie 2008; 4 (3):170-185
Full text:
Format PDF (Română/Romanian)

Abstract:

The hepatic metastasis process, a specific study subject within the carcinogenesis framework is characterized by the selection, at the primary tumor level, of a tumoral cell population able to undergo several mandatory stages, generally designed as the metastasis cascade. The study of the mechanisms involved in the biology of the metastasis, by molecular cell-to-cell and cell-to-matrix interactions, respectively, opens new perspectives for a clinical and therapeutic approach oriented towards the intrinsic events that govern over the transformation from normal to malignant. The article concentrates the information present in the publications mainstream, the text organization being focused on the angiogenesis, the overcoming adhesive interactions at the primary tumor, the disruption of the basement membrane followed by the initiation of tumoral invasion, the arrest and adhesion of metastatic tumor cells in target organs. The overview of the metastasis cascade from the point of view of the general rules acting disregarding the location is doubled by details referring strictly to the hepatic metastasis secondary to colorectal cancer. The presentation of some molecular biology notions supports the intention to achieve a connection between the pathologist’ and the surgeon’s insight.

KEY WORDS: METASTASIS, COLORECTAL CANCER, MECHANISM

Correspondence to: Irina-Draga Căruntu, MD, PhD, Professor, Department of Histology, University of Medicine and Pharmacy „Gr.T. Popa”, No. 16, Universităţii Street, Iaşi, Romania, 700115.



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.