Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | duminic„, 08 decembrie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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ACTUAL THERAPEUTIC OPTIONS IN HEPATOCELLULAR CARCINOMA
L. Miron, M. Marinca
Oncology Clinic, St. Spirridon University Hospital Iaşi
University of Medicine and Pharmacy Iaşi
Jurnalul de chirurgie 2008; 4 (3):186-193
Full text:
Format PDF (Română/Romanian)

Abstract:

Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide, with the number of new cases closely resembling the number of deaths. HCC incidence has doubled over the last 20 years in Europe. The management of HCC patients depends mainly on the extent and location of the tumor and the underlying liver disease. Three curative methods are currently available: orthotopic liver transplantation, surgical resection and local destruction. Local destruction of HCC is the most recent curative treatment that may be done using chemical (alcohol or acetic acid) or physical destruction by thermal ablation (cryotherapy, radiofrequency). Thermal ablation gives a more homogenous and larger necrosis and has replaced ethanol injection in many centers. Trans-arterial-chemo-embolisation (TACE) suggested a potential benefit: administration of intra-arterial radioactive lipiodol resulted in encouraging results in one randomised trial. Systemic chemotherapy has given disappointing results in inoperable HCC, possibly owing to the strong multidrug resistance gene expression. As novel molecular targeted therapy, sorafenib, an oral multikinase inhibitor that inhibits the VEGF receptor, is the only drug that improves median time to disease progression and median overall survival of the HCC patients. Identification of appropriate targets and effective therapies in HCC currently represents a significant challenge and new hope for the future.

KEY WORDS: HEPATOCELLULAR CARCINOMA, ABLATION, TARGETED THERAPIES

Correspondence to: Lucian Miron MD, PhD, Oncology Clinic, „St. Spiridon” Hospital Iaşi, Independendenţei Street, No.1, 700111; email:  



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.