Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 28 octombrie 2020
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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Ki67 PROGNOSTIC FACTOR IN GASTRIC CARCINOMAS
Luminiţa Ivan
Department of Pathology
Emergencies Army Hospital Iaşi
Jurnalul de chirurgie 2008; 4 (4): 308-312
Full text:
Format PDF (Română/Romanian)

Abstract:

Aims: Despite their importance, prognostic factors in gastric cancer are not well known. Material and methods: The study included surgical specimens from 40 patients with gastric carcinoma. All specimens were fixed in 10% buffered neutral pH formaldehyde and paraffin embedded. Histological sections were stained using current techniques: haematoxylin-eosin, trichromic van Gieson, and Alcian blue. Laurén histological classification with two main types of gastric carcinoma: intestinal and diffuse was used to classify the specimens. We assessed the proliferative activity by determining the percentage of immunoreactive cells for Ki67 antigen (AM297 antibody Biogenex) and comparing the Ki67 index with histological type. Results: Immunoreactivity was positive for ki-67 in all cases: 12 cases of gastric carcinoma intestinal type – low to moderate index, 26 cases of gastric carcinoma diffuse type – moderate to high index and 2 cases of mixed gastric carcinomas – low to moderate index. Conclusions: The positive rates for Ki67 along with histologic differentiation give us useful information regarding the evolution and the prognosis of gastric cancer. These observations prove that a high proliferative activity is a prognostic factor for a highly malignant phenotype of the tumor.

KEY WORDS: GASTRIC CANCER, KI67

Correspondence to: Luminiţa Ivan, MD, Department of Pathology, Emergencies Army Hospital Iaşi, Str. Gen Berthlot, No. 6, Iaşi, Romania



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.