Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | sâmbătă, 19 ianuarie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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CD 34 FACTOR AND METASTASES APPEARANCE IN LOCALLY ADVANCED BREAST CANCER
Camelia Chifu (1), C. Diaconu (1), Laurette Cozma (2), E. Carasevici (3), Niculina Florea (4),
Irina Florea (3), C. Dragomir (1)
(1) „Gr.T. Popa” University of Medicine and Pharmacy Iaşi
Third Surgical Unit, „St. Spiridon” Hospital Iaşi
(2) Immunology Laboratory , „St. Spiridon” Hospital Iaşi
(3) „Gr.T. Popa” University of Medicine and Pharmacy Iaşi, Department of Immunology
(4) Department of Pathology, „St. Spiridon” Hospital Iaşi
Jurnalul de chirurgie 2009; 5 (4): 365-369
Full text:
Format PDF (Română/Romanian)

Abstract:

Locally advanced breast cancer is a pathology characterized by local aggressiveness and by frequent local and distant recurrences. Although in the USA this stage of disease represents about 5% of all the breast cancers, in Romania the proportion may rise till 30-40%. With the introduction of neoadjuvant chemotherapy the 5 year survival in the III-rd stage breast cancer was estimated to reach 47% in 2003. Further evolution of targeted therapies make us hope to improve both survival and the quality of life of our patients. In our clinic, of the 1000 patients operated for a breast cancer during the last 10 years 39.4% were in a locally advanced stage. The purpose of this study was to identify whether CD 34 or vascular invasion are correlated to the appearance of metastases in locally advanced breast cancer. Of the two factors, CD 34 was the only one to be statistically correlated to the appearance of the metastases (p=0.048) and to their earlier onset (p=0.024) while classical and non quantified vascular invasion wasn’t. In fact, for patiens with CD 34 of the value „2” distant metastases appeared earlier than for CD 34 with the value of „1”. Evaluating locally advanced breast cancer by CD 34 will allow to chose a more fit therapy to prevent metastases, eventually by adding bevacizumab to the therapy in order to prevent tumour proliferation and for its anti-angiogenic effect.

KEY WORDS: LOCALLY ADVANCED BREAST CANCER, CD 34, VASCULAR INVASION, METASTASES

Correspondence to: Camelia Chifu, MD, PhD, Third Surgical Unit, „St. Spiridon” Hospital, Independenţei Street, No 1, 700111, Iaşi, Romania; e-mail:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.