Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | luni, 22 aprilie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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BROWN TUMOR OF THE FACIAL BONES
Violeta Trandafir (1), Daniela Trandafir (1), Otilia Boişteanu (2),
D. Gogălniceanu (2), Eugenia Popescu (1)
(1) OMF Clinic, „St. Spiridon” Hospital Iaşi
„Gr. T. Popa” University of Medicine and Pharmacy Iaşi
(2) The Faculty of Dentistry, „Apollonia” University Iaşi
Jurnalul de chirurgie 2010; 6 (4): 420-425
Full text:
Format PDF (Română/Romanian)

Abstract:

Brown tumor arises as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism. The lesion localizes in areas of intense bone resorbtion, and the bone defect becomes filled with fibroblastic tissue that can deform the bone and simulate a neoplastic process. Brown tumors can affect the mandible, maxilla, clavicle, ribs and pelvic bones. Most patients with hyperparathyroidism are asymptomatic. Skeletal changes may represent the first manifestations of the disease. Radiologically, brown tumor in the jaws presents as a well-defined radiolucent osteolytic lesion, making it hard to differentiate it from other maxillary expansive lesions that can present with a similar imaging. Brown tumors exhibit no pathognomonic histologic changes. Differentiating between a brown tumor and other giant-cell tumors may be very difficult, even with histology. A final diagnosis can be defined only by evaluating the radiological findings with histopathological, laboratory and clinical data. At present, brown tumor is considered as a reparative cellular process rather than a real neoplasia. This phenomenon is considered as pathognomonic of hyperparathyroidism secondary to renal failure, especially in patients on long-term hemodialysis. The initial treatment of brown tumor involves control of hyperparathyroidism, regardless of whether it is primary or secondary. The clinical management of brown tumor aims primarily to reduce the elevated parathyroid hormone levels by pharmacological treatment. Surgical treatment is reserved to nonresponders or to patients with painful symptomatology or alteration of normal function. Brown tumor can recur if hyperparathyroidism persists or recurs.

KEY WORDS: BROWN TUMOR, JAWS, HYPERPARATHYROIDISM, CHRONIC RENAL DISEASE

Correspondence to: Violeta Trandafir, MD, PhD, OMF Clinic, „St. Spiridon” Hospital Iaşi, str. Independenţei nr. 1, cod 700111; e-mail:  



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.