CLINICAL AND PATHOLOGICAL STUDY OF THE RESPONSE TO NEOADJUVANT RADIOCHEMOTHERAPY (RCT) IN ESOPHAGEAL SQUAMOUS CANCER (ESC)
Rodica Bîrlă (1), A. Hanna (1), A. Mocanu (1), Cristina Iosif (2), P. Hoară (1),
Cristina Gîndea (1), P. Surugiu (1), S. Constantinoiu (1)
(1) Clinic of General Surgery and Esophageal Surgery, “Sf. Maria” University Hospital
“Carol Davila” University of Medicine and Pharmacy Bucharest
(2) Pathology Department, “Sf. Maria” University Hospital
Jurnalul de chirurgie 2010; 6 (4): 438-443
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Abstract:

The multimodale treatment is encompassed in general efforts to improve the results of ESC treatment.This study was made retrospective and included 41 selected patients with ESC treated by neoadjuvant RCT in St. Mary Bucharest Hospital between 1998-2008. Therapeutic protocol included induction chemotherapy with 5-FU and Cisplatin combinated with radiotherapy in total dose 40 Gy, in 20 series. Only 28 patients benefit from esophagectomy and two field limfadenectomy. The evaluation of  response after RCT was done comparing the tumor dimension before and after RCT using the data offered by barium passage, upper endoscopy, echoendoscopy, computer tomography. In 29 cases we found clinical response (partial or complete) but pathological response only in 21 cases.The usual imagistic methods supraevaluate the patients who respond to neoadjuvant RCT in ESC and only the histopathological examination on resected specimen can offer the real rate of response.

KEY WORDS: ESOPHAGEAL SQUAMOUS CANCER, RADIOCHEMOTHERAPY

Correspondence to: Dr. Rodica Bîrlă, Clinica de Chirurgie Generală şi Esofagiană, Spitalul Clinic Sf. Maria, Bd-ul Ion Mihalache, nr. 37, sector 1, Bucureşti.