Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 21 august 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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IMMUNOHISTOCHEMICAL AND MOLECULAR EXPRESSION OF COX2 IN ESOPHAGOGASTRIC JONCTION ADENOCARCINOMA (EGJAC) AND PREMALIGNANT LESIONS CORELATED WITH CLINICAL DATAS
Cristina Iosif (1), Carmen Ardeleanu (1), Diana Ene (1), Rodica Birla (2), P. Hoara (2),
Cristina Gandea (2), P. Surugiu (2), N. Copca (3), S. Constantinoiu (2)
(1) INCD „Victor Babes”, Bucharest
(2) Clinic of General Surgery and Esophageal Surgery, “Sf. Maria” University Hospital
“Carol Davila” University of Medicine and Pharmacy Bucharest
(3) 2-nd Surgical Clinic, “Sf. Maria” University Hospital, Bucharest
Jurnalul de chirurgie 2010; 6 (4): 449-455
Full text:
Format PDF (Română/Romanian)

Abstract:

The aim of our study was to evaluate the expression of COX2 by immunohistochemical (IHC) and molecular metods on biopsies from patients with esophagites, Barrett’s esophagus (BE) and EGJADC and to correlate these findings with semnificative clinical datas (manometry, ph monitoring, medical and surgical tratament effects). We have evaluated by endoscopy with biopsy and IHC for COX2 , esophageal manometry and 24h pH monitoring 25 esophagitis and 21 BE. 54 EGJADC were tested by IHC for COX2 expression and also by RT-PCR on fresh tumoral tissue. Our results suggest that COX2 expression was correlated with manometry, ph monitoring and histopatholgical aspects. All EGJADCs tested for COX2 were positive but there was no statistical correlation with histologic type, grading and pTNM stage.

KEY WORDS: ESOPHAGOGASTRIC JONCTION ADENOCARCINOMA, COX2, ESOPHAGEAL MANOMETRY, PH MONITORING, RT-PCR, IMMUNOHISTOCHEMISTRY

Correspondence to: Cristina Iosif, MD, PhD, INCD „Victor Babes”, Bucharest



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.