Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | luni, 22 aprilie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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MORPHOLOGIC CATEGORIES AND REACTIVE INFLAMMATORY ASPECTS OF ADENOMA-CARCINOMA SEQUENCE. DIAGNOSTIC AND MANAGEMENT CRITERIA IN COLORECTAL TUMORS
Camelia Croitoru (1,2),  Daniela Jitaru (2), Simona Eliza Giuscă (3),
Irina-Draga Căruntu (4), E. Carasevici (1,2)
(1) “Gr. T Popa” University of Medicine and Pharmacy, Department of Immunology
(2) ”St. Spiridon” University Hospital Iaşi, Laboratory of Immunology and Genetics
(3) Emergency County Hospital, Sibiu, Department of Public Health and Management
(4) “Gr. T Popa”University of Medicine and Pharmacy, Iasi, Department of Histology
Jurnalul de chirurgie 2010; 6 (4): 473-480
Full text:
Format PDF (Română/Romanian)

Abstract:

In most cases colorectal carcinomas originates in adenomas, glandular paraneoplastic, noninvasive lesions. The adenoma – carcinoma sequence is already well caracterized as an event of risk for developing overt neoplasia. Adenoma management stages after endoscopic resection are: morphologic confirmation or infirmation of a possible adenocarcinoma, determining invasion depth,  adjusting histologic grade, evaluation of angiolymphatic invasion, estimation of security margins, conditions that could eventually be followed by completion of endoscopic resection. Morphologic diagnostic criteria of these lesion types can be correlated with particular aspects of inflammatory microenvironment succeding the development of adenoma – carcinoma sequence. We follow the evolution of inflammatory infiltrate in 21 cases of adenomas by evaluating the cells stained for common leukocyte antigen (CD45) in relation with the proliferation of epithelial tumor cells stained with Topoisomerase IIα. Particular aspects of this survey could offer some suggestion for later management of colorectal tumoral injury.

KEY WORDS: COLORECTAL ADENOMAS, TOPOISOMERASE IIΑ, INFLAMMATORY INFILTRATE, COMMON LEUKOCYTE ANTIGEN (CD45)

Correspondence to: Prof. Carasevici Eugen MD, PhD, ”St. Spiridon” University Hospital, Iaşi, Laboratory of Immunology and Genetics Bd Independentei 1, 700111 Iasi, e-mail:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.