Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | joi, 22 august 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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THE SIGNIFICANCE OF THE MORPHOLOGICAL PROFILE OF VARICOSE VEINS IN THE AETIOPATHOGENY OF CHRONIC VENOUS DISEASE
F. Comşa (1,2), Carmen Maria Ardelean (3), Cornelia Amălinei (1),
Simona Eliza Giuşcă (4), Irina-Draga Căruntu (1)
(1) Histology Department, „Gr. T. Popa” University of Medicine and Pharmacy Iaşi
(2) „Dr. Victor Babeş” Diagnosis and Treatment Medical Center, Bucureşti
(3) „Victor Babeş” National Institute of Research and Development Bucureşti
(4) Department of Public Health and Management,
University of Medicine and Pharmacy Iaşi
Jurnalul de chirurgie 2010; 6 (4): 481-492
Full text:
Format PDF (Română/Romanian)

Abstract:

The main stream of publications focused on chronic venous disease research includes many studies on etiological factors, clinical manifestations and treatment of varicose veins, but reports on biological, tissue and molecular events that might lead to venous wall dilatation are limited. In this context the present study analyses histopathological changes in varicose veins, our research being centered on endothelial, collagen, elastic and muscular structural components, of which features are altered in comparison with the normal status and can sustain the alteration of venous physiology. The studied group was formed by 13 patients with varicose veins: 8 in stage CEAP II-III (subgroup 1), 5 in stage CEAP IV-VI (subgroup 2), hospitalized in Dr. Victor Babes Diagnosis and Treatment Center, Bucharest. All cases underwent surgical treatment, 1 centimeter fragments of veins being taken from the saphenofemoral junction, internal saphenous vein, leg varicose package and perforating veins. The vein fragments were processed for histopathological exam with standard and special stains. The main morphological changes consisted of endothelial lesions, hypertrophy of intima (by fibrillar extracellular matrix) and hypertrophy of media (by smooth muscular cells hypertrophy and marked increasing of fibrillar extracellular matrix). The histopathological exam revealed the constant presence of the same lesions at the vein fragments taken from different sites and the lesions specific to the two stages of the varicose veins presented an important degree of overlapping. According to the clinical manifestations, the comparison between the histopathology of the lesions from stage CEAP II-III with those from the stage CEAP IV-VI shows only the dynamic evolution of the existing pathological substratum towards the complications of the disease. The morphological finding has double significance: aetiopathogenic, signifying that the high venous pressure acts irrespective of territory and venous diameter, and clinical, signifying that varicose veins disease requires early treatment measures.

KEY WORDS: VARICOSE VEINS, ENDOTHELIUM, COLLAGEN, ELASTIN, SMOOTH MUSCLE CELLS

Correspondence to: Prof. dr. Irina-Draga Căruntu, Disciplina Histologie, Universitatea de Medicină şi Farmacie „Gr. T. Popa” Iaşi; e-mail: .



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.