Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 21 august 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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TESTICULAR CANCER – CRITICAL APPRAISAL OF THE PATHOLOGY PROFILE
M. Marinca (1), Ludmila Liliac (2), Irina Draga Căruntu (2)
(1) Oncology Clinic, Faculty of Medicine
(2) Histology Department, Faculty of Medicine
„Gr. T. Popa” University of Medicine and Pharmacy  Iaşi
Jurnalul de chirurgie 2010; 6 (4): 505-516
Full text:
Format PDF (Română/Romanian)

Abstract:

Testicular cancer (TC) may originate in the structure of the seminiferous tubule or the interstitial tissue, but the vast majority (> 95%) arise from the germinal epithelium. Germ cell tumors (GCT) are classified as seminomas (S, 50% of TC), non-seminomas (NS, 40%), and tumors composed of several cell lines (mixed-type tumors, MT, 10%). We reevaluated the available specimens for 39 cases of GCT (15 S, 12 NS, 12 MT). The major distinction to be made was between pure S and NS (including MT), but additional data were obtained in order to assess and quantify several other histological features of potential interest (share of different tumor subtypes, cytoplasm staining, intratumoral necrosis, lymphocytic infiltration, invasion of tunica albuginea and rete testis, tumor emboli, spermatogenesis) not evaluated during the initial (diagnostic) examination. Their impact on disease-free (DFS) and overall survival (OS) was also evaluated. Mean follow-up duration was 47.11 months (range 4.73-104.0 months). We found the vascular component of the tumor (p=0,034) to be linked to DFS of NS and only the lymphocytic infiltrate (p=0,0001) to both DFS and OS in S. The pathology exam can be considered as an independent prognostic factor of utmost importance in TC, and might need to include additional information about these two aspects and possibly others, but research on a larger number of patients is needed.

KEY WORDS: TESTICULAR CANCER, PATHOLOGY, DIAGNOSIS, PROGNOSIS

Correspondence to: Mihai Marinca, MD, Oncology Clinic, St Spiridon University Hospital, Iaşi, str. Independenţei, nr. 1, 700111, e-mail: .



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.