Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | sâmbătă, 23 martie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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EPIDEMIOLOGY, ETIOPATHOLOGY AND DIAGNOSTIC OF HEPATOCELLULAR CARCINOMA
N. Vlad
„I. Tănăsescu-Vl. Buţureanu” First Surgical Clinic
„Gr. T. Popa” University of Medicine and Pharmacy Iaşi
Jurnalul de chirurgie 2011; 7 (1): 6-21
Full text:
Format PDF (Română/Romanian)

Abstract:

Hepatocellular Carcinoma (HCC) is among the most common of solid human malignancies, with an annual incidence of 100.000 new cases. The worldwide distribution of HCC is not uniform, the highest rates are found in Southeast Asia and Sub-Saharian Africa. The HCC imcidence in Romania varies between 4-10 cases to 100.000 inhabitants per year. HCC is more likely to develop in men than in women, the sex ratio being approximately 8:1 in high-incidence areas. Chronic hepatitis B virus and C virus have been implicated as important etiologic factors in the development  of HCC, being responsable for 80% of the cases. The most of the carcinomas are developped on the cirrhotic liver. A number of other risk factors also are involved in HCC: diabetes mellitus, obesity, chronic ethilism, oral contraceptives, smoking and dietary intake of aphlatoxines. HCC is usually diagnosed at a late stage. The clinical presentation are not typical, suggesting only the basic liver pathology. Ultrasounds, CT- scan and MRI confirm the presence of a mass in the liver. Alfa-fetoprotein (AFP), alfa-fetoprotein L3 fraction and des-gammacarboxiprotrombina (also known as PIVKA II test) are considered as serological markers for HCC. The indication of screening is for the patients with liver cirrhosis or chronic hepatitis B and/ or C virus. The level of AFP and liver ultrasounds are mandatory to be done as screening tests to every 6 months to the risk patients.

KEY WORDS: LIVER CIRRHOSIS; HEPATOCELLULAR CARCINOMA; RISK FACTORS; EPIDEMIOLOGY; DIAGNOSIS; ULTRASOUND; COMPUTED TOMOGRAPHY

Correspondence to: Nuţu Vlad, MD, Assistant Professor, First Surgical Clinic, St. Spiridon Hospital, Iaşi, bl. Independenţei 1, 700111; email:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.