Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | luni, 21 ianuarie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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CYTOKINES PROFILE IN THE PLASMA OF MALIGNANT MELANOMA PATIENTS
Natalia Cireap (2), Diana Narita (1), R. Ilina (2), A. Anghel (1), Elena Lazar (3) , T. Nicola (2)
1. Department of Surgical Oncology, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
2. Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
3. Department of Pathology, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
Jurnalul de chirurgie 2011; 7 (1): 54-63
Full text:
Format PDF (Română/Romanian)

Abstract:

Malignant melanoma is considered to be a prototype of an immunogenic tumor that express a variety of cytokines and growth factors that may stimulate tumor angiogenesis, growth and invasion. The purpose of this study was to analyze and compare the expression levels of a selected panel of twelve inflammatory cytokines/chemokines in the plasma of melanoma patients before any treatment with the expression levels of matched age and sex healthy controls. This study was performed in order to select the most appropriate profile of cytokines that could serve as markers for early diagnosis, prognostic and treatment. The study was performed on patients diagnosed with malignant melanoma that underwent surgery in 2010 compared with healthy controls, using a multi-analyte ELISArray kit. Our results showed a statistically significant increase in plasma levels of six inflammatory cytokines (IL-1β, IL-10, IL-17α, IFN-γ, TNF-α  and GM-CSF) (P between <10-4 and 0.01). For IL-1α, IL-2, IL-4, IL-6, IL-8 and IL-12, the plasma levels were also increased but the differences compared with healthy controls were not statistically significant. In conclusion, a complex network of cytokines seems to be triggered in the presence of invasive primary melanoma or metastatic melanoma and this cytokine response is involved in the regulation of melanoma cell growth and progression. Differences in cytokine profiles between melanoma patients and healthy subjects allowed for robust discrimination between these two groups, emphasize the advantage of multimarker analysis for discovery of new predictive serum biomarkers for melanoma and provide additional insights into the pathobiology of melanoma.

KEY WORDS: MALIGNANT MELANOMA, CYTOKINES, MULTIPLEXED ANALYSES, BIOMARKERS

Correspondence to: Natalia Cireap, MD, Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania, e-mail:



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.