Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | sâmbătă, 25 mai 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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THE MOLECULAR PROFILE OF BREAST CANCER: FROM GENES TO HISTOLOGICAL FEATURES
Carmen Ionescu, Cornelia Amălinei, Raluca Balan, Adriana Grigoraş, Irina-Draga Căruntu
Histology Department
„Gr.T. Popa” University of Medicine and Pharmacy Iaşi
Jurnalul de chirurgie 2011; 7 (2): 142-155
Full text:
Format PDF (Română/Romanian)

Abstract:

During the last decade, one of the main directions in the breast cancer research was oriented to the genetic profile, focusing on a deeper understanding of the molecular background that sustains the biological features (such as histological grade and metastasis potential) as well as on a better identification of some specific patterns, correlated with prognosis and therapeutic responses. The definition of new subtypes, in accordance with the genetic expression confirms, at the molecular level, the already existing concept of clinical and histological heterogeneity for the breast cancer. Despite a large number of papers dedicated to this subject, there are still unclear issues in the characterization of the molecular subtypes and, most probably, the number of subtypes known today is not the final one. This review, based on the information available in the publication mainstream, aims to offer a synthesis of the most recent concepts implemented in the breast carcinoma diagnosis. The text highlights the following topics: (i) the histological structure of the normal mammary gland, compulsory for the implementation of the new taxonomy and the hypothesis regarding the origin of breast cancer; (ii) the role of Stanford group in defining the genetic signature of breast cancer; (iii) the development and characteristics of the genetic tests available for breast cancer investigation; (iv) the usage of immunohistochemistry, as an alternative solution for genetic tests; (v) the molecular subtypes in correlation with immunohistochemical markers and histological features.

KEY WORDS: BREAST CANCER, MOLECULAR CLASSIFICATION, GENETIC TESTS, HISTOLOGICAL CLASSIFICATION

Correspondence to: Prof. dr. Irina-Draga Căruntu, Histology Department, „Gr.T. Popa” University of Medicine and Pharmacy Iaşi, str. Universitaţii, nr.16, e-mail:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.