Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | sâmbătă, 25 mai 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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THE MOLECULAR CHARACTERISTICS OF THE TUMOUR AND THE PROGNOSIS OF COLORECTAL CARCINOMA
S.T. Makkai-Popa (1,2), Șt. O. Georgescu (1,2),
E. Carasevici (1,3), E.Târcoveanu (1,2)
(1) “Gr. T. Popa” University of Medicine and Pharmacy, Iași
(2) First Surgical Clinic, “St. Spiridon” University Hospital, Iași
(3) Genetics and Immunology Laboratory “St. Spiridon” University Hospital, Iași
Jurnalul de chirurgie 2011; 7 (2): 156-165
Full text:
Format PDF (Engleză/English)

Abstract:

Due to the high rate of incidence and the overall mortality, colorectal cancer is one of the most important medical problems modern medicine has to deal with. A lot of research has been done in order to understand the molecular basis of the carcinogenesis process in colorectal adenocarcinoma and now the evolution of the colorectal cancer from normal epithelial cell to cancer cell is one of the best understood models of carcinogenesis. In order to fully understand this process one must have basic knowledge of the histology and the genetics of colorectal adenocarcinoma. Also of great importance is the role that the immune system has to play in the development and progression or regression of this type of cancer – from the basic immune response to the presence of the neoplastic cells, to the immune response that is caused by central necrosis which can lead to stimulation of tumour growth and finally to the immune response that is responsible for the development of cancer in the presence of chronic inflammation. The reason why the biology of the colorectal cancer is so important is that it can not only lead to finding new ways of treatment but mostly because it can lead to a better staging system than the classical Dukes staging system, which in turn can correct under-treatment or over-treatment of colorectal cancer lesions.

KEY WORDS: COLORECTAL CANCER, MUTATIONS, SPECIFIC IMMUNE RESPONSE, INNATE IMMUNE RESPONSE, IMMUNE SURVEILLANCE

Correspondence to: Makkai-Popa Silviu-Tiberiu, “Sf. Spiridon” Hospital, Iași – First Surgical Clinic, Independentei Blvd., No 1, Iasi, Romania; e-mail:



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.