Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 21 august 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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HEPATIC ARTERIAL INFUSION AND INTRAVENOUS CHEMOTHERAPY IN UNRESECTABLE LIVER METASTASES FROM COLORECTAL CANCER VERSUS SYSTEMIC CHEMOTHERAPY ALONE
C.Popa (1)(*), S. Simion (1), B. Popa (2), T. Potecă (1), Sânziana Ionescu (1)
(1) Clinic of General Surgery, Colentina Hospital
(*) PhD student “Carol Davila” University of Medicine and Pharmacy Bucharest
(2) Angiography Laboratory, Floreasca Emergency Hospital Bucharest,
“Carol Davila” University of Medicine and Pharmacy Bucharest
Jurnalul de chirurgie 2011; 7 (3): 374-379
Full text:
Format PDF (Română/Romanian)

Abstract:

Methods: In collaboration with Angiography Lab - “Floreasca” Emergency Hospital ,14 patients with hepatic metastases of colorectal origin, unresecable, were administered  hepatic intraarterial chemotherapy and 22 patients were administered only systemic chemotherapy with Oxaliplatinum 150 mg, 5 Fluorouracil 2500 mg, Follinate calcium 150 mg. Results: It was thus demonstrated that the therapy using HAI with 5 Fluorouracil, Pharmarubicin, Iomeron, in association with a systemic regimen based on Oxaliplatin and 5 Fluorouracil (an average of 4 cures) was efficient in 64% of cases . Moreover, tumor response to therapy allowed consequent curative resection or RFA in 18% of cases. OS was of 20 months and PFS of 11months. In conclusion, administering chemotherapy by hepatic arterial infusion is both efficient and well tolerated in unresecable metastases of colo-rectal cancers. Associating systemic chemotherapy improves on the response rates. The femoral catheter implant is feasible and easies the administration of palliative and  neo-adjuvant treatments.

KEY WORDS: HEPATIC ARTERIAL INFUSION (HAI) , SISTEMIC CHEMOTERAPY, UNRESECABLE LIVER METASTASES, COLORECTAL CANCER

Correspondence to: Associate Professor Sorin Simion / Assistant Professor Cosmin Popa, Clinic of General Surgery, Colentina Hospital, Şoseaua Ştefan cel Mare no. 19-21, Sector 2, 020125, Bucharest, România; e-mail:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.