Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | luni, 18 noiembrie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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EPIDEMIOLOGICAL STUDY REGARDING FAMILY AGGREGATION IN PATIENTS DIAGNOSED WITH COLORECTAL CANCER
Maria Maxim (*), Anca Trifan
(*) PhD student „Gr.T. Popa” University of Medicine and Pharmacy Iaşi
Gastroenterology and Hepatology Center Iaşi, St Spiridon University Hospital
„Gr.T. Popa” University of Medicine and Pharmacy Iaşi
Jurnalul de chirurgie 2011; 7 (3): 417-423
Full text:
Format PDF (Română/Romanian)

Abstract:

Colorectal cancer (CRC) is the second leading cause of cancer death both in the USA and Europe. Approximately 20% of all CRC cases occur in patients with family aggregation, but they do not respect a hereditary transmission model. The aim of this study was to establish the incidence of the disease and the clinical evolution aspects of CRC in patients with  family history of colorectal neoplasm. Methods: We have studied the medical records and the histopathological findings of 460 patients diagnosed with CRC at the Institute of Gastroenterology and Hepatology, Iasi, during the period November 2007-December 2009. The patients were grouped as follows: the first group – patients with family history of CRC (n=56); the 2nd group – patients with no family history (n=318); the 3rd group – patients with familial history of neoplasia, others than CRC (n=86). Data on gender, age, provenience environment, tumor location, anatomical-pathological aspects, stage and synchronous lesions have been evaluated. Results: CRC family aggregation was found at 12.2% of the total cases of CRC, 85.7% of these patients had first-degree relatives. CRC was more frequent in males, predominantly from the urban area, regardless to the precence or the absence of the familial history of CRC. The highest incidence of CRC in patients with familial history was in the 6th decade versus the patients with no family history, where the disease appears two decades later. The location of CRC prevails in the rectum and the sigmoid colon, especially in patients with no family history. In patients with familial history of CRC one-third of cases are located in the proximal colon, most of them being in advanced stages. Conclusions: Family history of CRC is corelated to an increased risk of the disease, and therefore, screening programs of the relatives of patients with CRC is a necessary.

KEY WORDS: COLORECTAL CANCER, FAMILY HISTORY OF CANCER, DIAGNOSIS

Correspondence to: Maria Maxim, MD PhD student „Gr.T. Popa” University of Medicine and Pharmacy Iaşi, Gastroenterology and Hepatology Center Iaşi, St Spiridon University Hospital, str. Independentei nr. 1, 700111, e-mail:



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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.