Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 20 ianuarie 2021
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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EVALUATION OF THE NEOADJUVANT TREATMENT’S TUMOR RESPONSE IN LOCALLY ADVANCED LOW RECTAL CANCER. ONE SURGICAL TEAM EXPERIENCE
Maria-Gabriela Anitei, V. Scripcariu
Universitatea de Medicina si Farmacie ,,Gr.T. Popa” Iasi,
Departamentul de chirurgie, Clinica Chirurgie, Institutul Regional de Oncologie Iasi
Jurnalul de chirurgie (Iaşi). 2013; 9(1): 35-41.
Full text:
Format PDF (Română/Romanian)

Abstract:

BACKGROUND: The gold standard in low rectal cancer today is a multimodal approach, tailored for each patient. AIM: The aim of this study was to evaluate the histopathological tumor response after long term neoadjuvant chemoradiation in locally advanced rectal cancer and the possibilities of preserving the anal sphincter. MATERIALS AND METHODS: We retrospectively analyzed 115 cases of advanced low rectal cancer that received preoperative treatment and underwent rectal resection with total mesorectal excision. The pretreatment tumor-node-metastasis stage (cTNM) was as follows: 38 patients were assigned as stage II and 77 patients as stage III. Long-term radiotherapy was delivered at a median dose of 47.24 Gy (± 5.47 Gy) and for 80 patients (69.56%) was associated with chemotherapy. The tumors “downstaging” was defined as any pathologic stage (ypTNM) less than pretreatment imagistic stage (cTNM). Sphincter-sparing surgery after preoperative radiotherapy was performed in safety oncological conditions. RESULTS: Comparison of preoperative and pathologic staging revealed that the depth of invasion was downstaged in 42 patients (36.52%) and lymph nodes status was downstaged in 16 patients of 77 patients (20.77%). Complete regression with absence of residual cancer was reported in 6 patients (5.21%). The sphincter sparing surgery was performed in 38 patients (33.04%).The procedures performed were resections considered low and very low, with total mesorectal excision and ratio hand sewn anastomosis/double stappled anastomosis was 20 to 18. CONCLUSION: The response to neoadjuvant treatment in rectal cancer is an important factor in preserving the anal sphincter in low rectal cancer.

HOW TO CITE: Anitei MG, Scripcariu V. [Evaluation of the neoadjuvant treatment’s tumor response in locally advanced low rectal cancer. One surgical team experience]. Jurnalul de chirurgie (Iasi). 2013; 9(1): 35-41.
DOI: 10.7438/1584-9341-9-1-5.


: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.