Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 20 ianuarie 2021
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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Cătălina Mihai, Mihaela Dranga, M. Badea, Otilia Nedelciuc, Cristina Cijevschi Prelipcean
Universitatea de Medicină şi Farmacie „Gr.T. Popa” Iaşi
Institutul de Gastroenterologie şi Hepatologie Iaşi, Spitalul „Sf. Spiridon” Iaşi
Jurnalul de chirurgie (Iaşi) 2013; 9(2): 107-111.
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Proton pump inhibitors (PPI) have been widely used since 1989 because they are highly effective for acid-related conditions. As a class, PPIs are among the safest of pharmacologic agents. In the last years concerns have risen regarding potential of adverse events due to PPI use. These include cancer risk (stomach and colorectal cancer), infection risk (pneumonia, Clostridium difficile associated diarrhea, small intestinal bacterial overgrowth, spontaneous bacterial peritonitis, interstitial nephritis), metabolic effects on bone density with osteoporotic fractures, alteration of absorption of vitamins and minerals and the pharmacodynamic interaction with the metabolism of other medications by the hepatic cytochrome P450 enzyme systems (e.g., clopidogrel). Almost the entire evidence base regarding the safety of PPI therapy is composed of retrospective non-randomized studies that demonstrate association but not causality and are limited by potential confounding factors. There is no evidence to support any benefit of changing existing clinical practice for preventing any of the potential adverse effects associated with PPI therapy. Therefore, in patients with appropriate indications for PPI, we should avoid continuous and high-dose therapy, considering on-demand therapy in suitable patients and step-down strategy.

HOW TO CITE: Mihai C, Dranga M, Badea M, Nedelciuc O, Mihai C. [Proton pump inhibitors between benefits and risks]. Jurnalul de chirurgie (Iaşi). 2013; 9(2): 107-111. DOI: 10.7438/1584-9341-9-2-1.

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Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.